Ontology highlight
ABSTRACT:
SUBMITTER: Beausoleil SA
PROVIDER: S-EPMC514446 | biostudies-other | 2004 Aug
REPOSITORIES: biostudies-other
Beausoleil Sean A SA Jedrychowski Mark M Schwartz Daniel D Elias Joshua E JE Villén Judit J Li Jiaxu J Cohn Martin A MA Cantley Lewis C LC Gygi Steven P SP
Proceedings of the National Academy of Sciences of the United States of America 20040809 33
Determining the site of a regulatory phosphorylation event is often essential for elucidating specific kinase-substrate relationships, providing a handle for understanding essential signaling pathways and ultimately allowing insights into numerous disease pathologies. Despite intense research efforts to elucidate mechanisms of protein phosphorylation regulation, efficient, large-scale identification and characterization of phosphorylation sites remains an unsolved problem. In this report we desc ...[more]