Ontology highlight
ABSTRACT:
SUBMITTER: Panciera T
PROVIDER: S-EPMC5145813 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Cell stem cell 20160915 6
The ability to induce autologous tissue-specific stem cells in culture could have a variety of applications in regenerative medicine and disease modeling. Here we show that transient expression of exogenous YAP or its closely related paralogue TAZ in primary differentiated mouse cells can induce conversion to a tissue-specific stem/progenitor cell state. Differentiated mammary gland, neuronal, and pancreatic exocrine cells, identified using a combination of cell sorting and lineage tracing appro ...[more]