MicroRNA and gene co-expression networks characterize biological and clinical behavior of rhabdomyosarcomas.
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ABSTRACT:
SUBMITTER: Missiaglia E
PROVIDER: S-EPMC5157784 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Publications
MicroRNA and gene co-expression networks characterize biological and clinical behavior of rhabdomyosarcomas.
Missiaglia Edoardo E Shepherd Chris J CJ Aladowicz Ewa E Olmos David D Selfe Joanna J Pierron Gaëlle G Delattre Olivier O Walters Zoe Z Shipley Janet J
Cancer letters 20161029
Rhabdomyosarcomas (RMS) in children and adolescents are heterogeneous sarcomas broadly defined by skeletal muscle features and the presence/absence of PAX3/7-FOXO1 fusion genes. MicroRNAs are small non-coding RNAs that regulate gene expression in a cell context specific manner. Sequencing analyses of microRNAs in 64 RMS revealed expression patterns separating skeletal muscle, fusion gene positive and negative RMS. Integration with parallel gene expression data assigned biological functions to 12 ...[more]
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