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Nuclear DNA damage signalling to mitochondria in ageing.

ABSTRACT: Mitochondrial dysfunction is a hallmark of ageing, and mitochondrial maintenance may lead to increased healthspan. Emerging evidence suggests a crucial role for signalling from the nucleus to mitochondria (NM signalling) in regulating mitochondrial function and ageing. An important initiator of NM signalling is nuclear DNA damage, which accumulates with age and may contribute to the development of age-associated diseases. DNA damage-dependent NM signalling constitutes a network that includes nuclear sirtuins and controls genomic stability and mitochondrial integrity. Pharmacological modulation of NM signalling is a promising novel approach for the prevention and treatment of age-associated diseases.

SUBMITTER: Fang EF

PROVIDER: S-EPMC5161407 | biostudies-other | 2016 May

REPOSITORIES: biostudies-other

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Nuclear DNA damage signalling to mitochondria in ageing.

Fang Evandro Fei EF Scheibye-Knudsen Morten M Chua Katrin F KF Mattson Mark P MP Croteau Deborah L DL Bohr Vilhelm A VA

Nature reviews. Molecular cell biology 20160309 5

Mitochondrial dysfunction is a hallmark of ageing, and mitochondrial maintenance may lead to increased healthspan. Emerging evidence suggests a crucial role for signalling from the nucleus to mitochondria (NM signalling) in regulating mitochondrial function and ageing. An important initiator of NM signalling is nuclear DNA damage, which accumulates with age and may contribute to the development of age-associated diseases. DNA damage-dependent NM signalling constitutes a network that includes nuc ...[more]

PMID: 26956196

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