Reshaping a therapeutic CD4 antibody.
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ABSTRACT:
SUBMITTER: Gorman SD
PROVIDER: S-EPMC51622 | biostudies-other | 1991 May
REPOSITORIES: biostudies-other
Publications
Reshaping a therapeutic CD4 antibody.
Gorman S D SD Clark M R MR Routledge E G EG Cobbold S P SP Waldmann H H
Proceedings of the National Academy of Sciences of the United States of America 19910501 10
An immunosuppressive rat antibody (Campath-9) against human CD4 has been reshaped for use in the management of autoimmunity and the prevention of graft rejection. Two different forms of the reshaped antibody were produced that derive their heavy chain variable region framework sequences from the human myeloma proteins KOL or NEW. When compared to a chimeric form of the CD4 antibody, the avidity of the KOL-based reshaped antibody was only slightly reduced, whereas that of the NEW-based reshaped a ...[more]
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