Ontology highlight
ABSTRACT:
SUBMITTER: Muriel O
PROVIDER: S-EPMC5170863 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Molecular biology of the cell 20160907 21
We used in vivo and in vitro strategies to study the mechanisms of multivesicular endosome biogenesis. We found that, whereas annexinA2 and ARP2/3 mediate F-actin nucleation and branching, respectively, the ERM protein moesin supports the formation of F-actin networks on early endosomes. We also found that moesin plays no role during endocytosis and recycling to the plasma membrane but is absolutely required, much like actin, for early-to-late-endosome transport and multivesicular endosome forma ...[more]