Ontology highlight
ABSTRACT:
SUBMITTER: Biju MP
PROVIDER: S-EPMC517905 | biostudies-other | 2004 Oct
REPOSITORIES: biostudies-other
Biju Mangatt P MP Neumann Aaron K AK Bensinger Steven J SJ Johnson Randall S RS Turka Laurence A LA Haase Volker H VH
Molecular and cellular biology 20041001 20
The von Hippel-Lindau gene product (pVHL) targets the alpha subunit of basic helix-loop-helix transcription factor hypoxia-inducible factor (HIF) for proteasomal degradation. Inactivation of pVhl in the mouse germ line results in embryonic lethality, indicating that tight control of Hif-mediated adaptive responses to hypoxia is required for normal development and tissue function. In order to investigate the role of pVhl in T-cell development, we generated mice with thymocyte-specific inactivatio ...[more]