Ontology highlight
ABSTRACT:
SUBMITTER: Jablonska B
PROVIDER: S-EPMC5187440 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Jablonska Beata B Gierdalski Marcin M Chew Li-Jin LJ Hawley Teresa T Catron Mackenzie M Lichauco Arturo A Cabrera-Luque Juan J Yuen Tracy T Rowitch David D Gallo Vittorio V
Nature communications 20161219
Regenerative processes in brain pathologies require the production of distinct neural cell populations from endogenous progenitor cells. We have previously demonstrated that oligodendrocyte progenitor cell (OPC) proliferation is crucial for oligodendrocyte (OL) regeneration in a mouse model of neonatal hypoxia (HX) that reproduces diffuse white matter injury (DWMI) of premature infants. Here we identify the histone deacetylase Sirt1 as a Cdk2 regulator in OPC proliferation and response to HX. HX ...[more]