The dynamics of filament assembly define cytoskeletal network morphology.
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ABSTRACT:
SUBMITTER: Foffano G
PROVIDER: S-EPMC5187503 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Publications
The dynamics of filament assembly define cytoskeletal network morphology.
Foffano Giulia G Levernier Nicolas N Lenz Martin M
Nature communications 20161221
The actin cytoskeleton is a key component in the machinery of eukaryotic cells, and it self-assembles out of equilibrium into a wide variety of biologically crucial structures. Although the molecular mechanisms involved are well characterized, the physical principles governing the spatial arrangement of actin filaments are not understood. Here we propose that the dynamics of actin network assembly from growing filaments results from a competition between diffusion, bundling and steric hindrance, ...[more]
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