Ontology highlight
ABSTRACT:
SUBMITTER: Smith-Vikos T
PROVIDER: S-EPMC5191881 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Smith-Vikos Thalyana T Liu Zuyun Z Parsons Christine C Gorospe Myriam M Ferrucci Luigi L Gill Thomas M TM Slack Frank J FJ
Aging 20161101 11
In <i>C. elegans</i>, miRNAs are genetic biomarkers of aging. Similarly, multiple miRNAs are differentially expressed between younger and older persons, suggesting that miRNA-regulated biological mechanisms affecting aging are evolutionarily conserved. Previous human studies have not considered participants' lifespans, a key factor in identifying biomarkers of aging. Using PCR arrays, we measured miRNA levels from serum samples obtained longitudinally at ages 50, 55, and 60 from 16 non-Hispanic ...[more]