Ontology highlight
ABSTRACT:
SUBMITTER: van de Ven RA
PROVIDER: S-EPMC5192218 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Nature communications 20161222
Spatiotemporal activation of RhoA and actomyosin contraction underpins cellular adhesion and division. Loss of cell-cell adhesion and chromosomal instability are cardinal events that drive tumour progression. Here, we show that p120-catenin (p120) not only controls cell-cell adhesion, but also acts as a critical regulator of cytokinesis. We find that p120 regulates actomyosin contractility through concomitant binding to RhoA and the centralspindlin component MKLP1, independent of cadherin associ ...[more]