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Degradation in intrinsic connectivity networks across the Alzheimer's disease spectrum.


ABSTRACT: Changes in intrinsic functional connectivity (iFC) have been reported at various stages of the Alzheimer's disease (AD) spectrum. We aimed to investigate such alterations over a variety of large-scale intrinsic brain networks (iBNs) across the spectrum of amyloid ? positivity and uncover their relation to cognitive impairment.Eight iBNs were defined from resting-state functional magnetic resonance imaging data. In amyloid ?-positive healthy subjects, prodromal, and AD patients (N = 70), within-network iFC (intra-iFC) and between-network iFC (inter-iFC) were correlated with scores of cognitive impairment.Across all iBNs, a general degradation in intra-iFC along the scale of cognitive impairment severity was found. Only subtle changes in inter-iFC were identified.Across the AD spectrum, changes in iFC that are strongly related to cognitive impairment occur within an extensive variety of networks.

SUBMITTER: Nuttall R 

PROVIDER: S-EPMC5198881 | biostudies-other | 2016

REPOSITORIES: biostudies-other

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Degradation in intrinsic connectivity networks across the Alzheimer's disease spectrum.

Nuttall Rachel R   Pasquini Lorenzo L   Scherr Martin M   Sorg Christian C  

Alzheimer's & dementia (Amsterdam, Netherlands) 20161210


<h4>Introduction</h4>Changes in intrinsic functional connectivity (iFC) have been reported at various stages of the Alzheimer's disease (AD) spectrum. We aimed to investigate such alterations over a variety of large-scale intrinsic brain networks (iBNs) across the spectrum of amyloid β positivity and uncover their relation to cognitive impairment.<h4>Methods</h4>Eight iBNs were defined from resting-state functional magnetic resonance imaging data. In amyloid β-positive healthy subjects, prodroma  ...[more]

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