Degradation in intrinsic connectivity networks across the Alzheimer's disease spectrum.
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ABSTRACT:
SUBMITTER: Nuttall R
PROVIDER: S-EPMC5198881 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Publications
Degradation in intrinsic connectivity networks across the Alzheimer's disease spectrum.
Nuttall Rachel R Pasquini Lorenzo L Scherr Martin M Sorg Christian C
Alzheimer's & dementia (Amsterdam, Netherlands) 20161210
<h4>Introduction</h4>Changes in intrinsic functional connectivity (iFC) have been reported at various stages of the Alzheimer's disease (AD) spectrum. We aimed to investigate such alterations over a variety of large-scale intrinsic brain networks (iBNs) across the spectrum of amyloid β positivity and uncover their relation to cognitive impairment.<h4>Methods</h4>Eight iBNs were defined from resting-state functional magnetic resonance imaging data. In amyloid β-positive healthy subjects, prodroma ...[more]
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