Ontology highlight
ABSTRACT:
SUBMITTER: Benkafadar N
PROVIDER: S-EPMC5210089 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
EMBO molecular medicine 20170101 1
Cisplatin is a widely used chemotherapy drug, despite its significant ototoxic side effects. To date, the mechanism of cisplatin-induced ototoxicity remains unclear, and hearing preservation during cisplatin-based chemotherapy in patients is lacking. We found activation of the ATM-Chk2-p53 pathway to be a major determinant of cisplatin ototoxicity. However, prevention of cisplatin-induced ototoxicity is hampered by opposite effects of ATM activation upon sensory hair cells: promoting both outer ...[more]