Ontology highlight
ABSTRACT:
SUBMITTER: Wu L
PROVIDER: S-EPMC5214705 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Wu Ling L Zhang Shu S Shkhyan Ruzanna R Lee Siyoung S Gullo Francesca F Eliasberg Claire D CD Petrigliano Frank A FA Ba Kai K Wang Jing J Lin Yunfeng Y Evseenko Denis D
JCI insight 20170112 1
Osteoarthritis is the most common form of arthritis, and pain relief with opioid-like drugs is a commonly used therapeutic for osteoarthritic patients. Recent studies published by our group showed that the kappa opioid receptor (KOR) is highly expressed during human development in joint-forming cells. However, the precise role of this receptor in the skeletal system remains elusive. The main aim of the current study was to investigate the role of KOR signaling in synovial and cartilaginous tissu ...[more]