Ontology highlight
ABSTRACT:
SUBMITTER: Corey JL
PROVIDER: S-EPMC521479 | biostudies-other | 1994 Feb
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19940201 3
A cocaine-sensitive, high-affinity Drosophila serotonin (5-hydroxytryptamine; 5HT) transporter cDNA, denoted dSERT1, was isolated and characterized in oocytes. dSERT1 shows little transport of other monoamines and is Na+ and Cl- dependent. Sequence analysis indicates 12 putative transmembrane domains and strong homologies (approximately 50%) among dSERT1 and mammalian 5HT, norepinephrine, and dopamine transporters. Interestingly, the pharmacological properties of dSERT1, including sensitivity to ...[more]