Ontology highlight
ABSTRACT:
SUBMITTER: Fujikura D
PROVIDER: S-EPMC5216082 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Nature communications 20170103
Expansion of autoreactive follicular helper T (Tfh) cells is tightly restricted to prevent induction of autoantibody-dependent immunological diseases, such as systemic lupus erythematosus (SLE). Here we show expression of an orphan immune regulator, death receptor 6 (DR6/TNFRSF21), on a population of Tfh cells that are highly expanded in lupus-like disease progression in mice. Genome-wide screening reveals an interaction between syndecan-1 and DR6 resulting in immunosuppressive functions. Import ...[more]