Ontology highlight
ABSTRACT:
SUBMITTER: Tian Y
PROVIDER: S-EPMC5216793 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
Tian Yu Y Tang Bo B Wang Chengye C Sun Deguang D Zhang Rixin R Luo Nan N Han Zhao Z Liang Rui R Gao Zhenming Z Wang Liming L
Oncotarget 20160701 29
Metformin plays an anti-proliferative role in tumor cells in many types of cancer. However, the correlation between metformin and sensitivity to chemotherapeutic agents in hepatocellular carcinoma (HCC) and the relevant mechanism are unclear. The present study showed that HCC patients with type 2 diabetes mellitus benefited from metformin administration, with a longer overall survival. Metformin resensitized Bel-7402/5-fluorouracil (Bel/Fu) cells to 5-fluorouracil (5-Fu) in vitro and in vivo, an ...[more]