Ontology highlight
ABSTRACT:
SUBMITTER: Park YS
PROVIDER: S-EPMC5217008 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
Oncotarget 20160701 30
Pyruvate kinase muscle type 2 (PKM2) exhibits post-translational modifications in response to various signals from the tumor microenvironment. Insulin-like growth factor 1 (IGF-1) is a crucial signal in the tumor microenvironment that promotes cell growth and survival in many human cancers. Herein, we report that AKT directly interacts with PKM2 and phosphorylates it at Ser-202, which is essential for the nuclear translocation of PKM2 protein under stimulation of IGF-1. In the nucleus, PKM2 bind ...[more]