Ontology highlight
ABSTRACT:
SUBMITTER: Kulandavelu S
PROVIDER: S-EPMC5223744 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Kulandavelu Shathiyah S Karantalis Vasileios V Fritsch Julia J Hatzistergos Konstantinos E KE Loescher Viky Y VY McCall Frederic F Wang Bo B Bagno Luiza L Golpanian Samuel S Wolf Ariel A Grenet Justin J Williams Adam A Kupin Aaron A Rosenfeld Aaron A Mohsin Sadia S Sussman Mark A MA Morales Azorides A Balkan Wayne W Hare Joshua M JM
Journal of the American College of Cardiology 20161201 22
<h4>Background</h4>Pim1 kinase plays an important role in cell division, survival, and commitment of precursor cells towards a myocardial lineage, and overexpression of Pim1 in ckit<sup>+</sup> cardiac stem cells (CSCs) enhances their cardioreparative properties.<h4>Objectives</h4>The authors sought to validate the effect of Pim1-modified CSCs in a translationally relevant large animal preclinical model of myocardial infarction (MI).<h4>Methods</h4>Human cardiac stem cells (hCSCs, n = 10), hckit ...[more]