Ontology highlight
ABSTRACT:
SUBMITTER: Padovano V
PROVIDER: S-EPMC5231895 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Molecular biology of the cell 20161123 2
Autosomal dominant polycystic kidney disease is caused by mutations in the genes encoding polycystin-1 (PC1) and polycystin-2 (PC2), which form an ion channel complex that may mediate ciliary sensory processes and regulate endoplasmic reticulum (ER) Ca<sup>2+</sup> release. Loss of PC1 expression profoundly alters cellular energy metabolism. The mechanisms that control the trafficking of PC1 and PC2, as well as their broader physiological roles, are poorly understood. We found that O<sub>2</sub> ...[more]