Ontology highlight
ABSTRACT:
SUBMITTER: Yamada R
PROVIDER: S-EPMC5233908 | biostudies-other | 2017 Feb
REPOSITORIES: biostudies-other
Yamada Ryuichi R Deshpande Sonali A SA Keebaugh Erin S ES Ehrlich Margaux R MR Soto Obando Alina A Ja William W WW
The journals of gerontology. Series A, Biological sciences and medical sciences 20160419 2
The Drosophila GeneSwitch system facilitates the spatial and temporal control of gene expression through dietary supplementation of mifepristone (RU486). Because experimental and control groups differ only by treatment with RU486, confounding results from using flies of different genetic backgrounds are eliminated, making GeneSwitch especially useful in studies of aging. However, the effect of RU486 itself on longevity has not been well characterized, particularly in relation to nutritional stat ...[more]