Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC5238461 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
ACS medicinal chemistry letters 20161129 1
Development of orally bioavailable nonsteroidal selective estrogen receptor downregulators (SERDs) provides clinical opportunities for the long-term treatment and adjuvant therapy of breast cancer at all stages. We describe the design, synthesis, and identification of a boron-modified GW7604 derivative (GLL398, <b>9</b>), a SERD candidate, in which a boronic acid functional group replaces the phenolic hydroxyl group of GW7604. Compound <b>9</b> strongly binds to ERα in a fluorescence resonance e ...[more]