Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC5239492 | biostudies-other | 2016 Aug
REPOSITORIES: biostudies-other
Li Miao M Li Xi X Zhuang Yan Y Wang Yan Y Burow Matthew E ME Collins-Burow Bridgette B Xue Min M Song Chengjie C Shan Bin B
Oncotarget 20160801 32
The gene expression signatures of the molecular intrinsic subtypes of breast cancer are regulated by epigenetic mechanisms such as methylation of CpG islands in gene promoters. Epigenetic codes can be regulated by the tumor microenvironment. The Claudin-low subtype is associated with triple-negative invasive ductal carcinomas in patients. Herein we explored epigenetic regulation of gene expression in the Claudin-low breast cancer cells by extracellular matrix (ECM), a key component of the tumor ...[more]