Ontology highlight
ABSTRACT:
SUBMITTER: Hao Z
PROVIDER: S-EPMC5241832 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Hao Zhenyue Z Sheng Yi Y Duncan Gordon S GS Li Wanda Y WY Dominguez Carmen C Sylvester Jennifer J Su Yu-Wen YW Lin Gloria H Y GH Snow Bryan E BE Brenner Dirk D You-Ten Annick A Haight Jillian J Inoue Satoshi S Wakeham Andrew A Elford Alisha A Hamilton Sara S Liang Yi Y Zúñiga-Pflücker Juan C JC He Housheng Hansen HH Ohashi Pamela S PS Mak Tak W TW
Nature communications 20170113
T-cell proliferation is regulated by ubiquitination but the underlying molecular mechanism remains obscure. Here we report that Lys-48-linked ubiquitination of the transcription factor KLF4 mediated by the E3 ligase Mule promotes T-cell entry into S phase. Mule is elevated in T cells upon TCR engagement, and Mule deficiency in T cells blocks proliferation because KLF4 accumulates and drives upregulation of its transcriptional targets E2F2 and the cyclin-dependent kinase inhibitors p21 and p27. T ...[more]