Ontology highlight
ABSTRACT:
SUBMITTER: Shatirishvili M
PROVIDER: S-EPMC5260879 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Shatirishvili M M Burk A S AS Franz C M CM Pace G G Kastilan T T Breuhahn K K Hinterseer E E Dierich A A Bakiri L L Wagner E F EF Ponta H H Hartmann T N TN Tanaka M M Orian-Rousseau V V
Cell death & disease 20161110 11
CD44, a large family of transmembrane glycoproteins, plays decisive roles in physiological and pathological conditions. CD44 isoforms are involved in several signaling pathways essential for life such as growth factor-induced signaling by EGF, HGF or VEGF. CD44 is also the main hyaluronan (HA) receptor and as such is involved in HA-dependent processes. To allow a genetic dissection of CD44 functions in homeostasis and disease, we generated a Cd44 floxed allele allowing tissue- and time-specific ...[more]