Dataset Information

Paternal age and schizophrenia: a population based cohort study.

ABSTRACT: OBJECTIVE: To investigate the association of paternal age at conception with the risk of offspring developing schizophrenia. DESIGN: A population based cohort study. SETTING: Sweden. SUBJECTS: 754,330 people born in Sweden between 1973 and 1980 and still alive and resident in Sweden at age 16 years. MAIN OUTCOME MEASURES: Hospital admission with schizophrenia or non-schizophrenic, non-affective psychosis. RESULTS: After adjustment for birth related exposures, socioeconomic factors, family history of psychosis, and early parental death the overall hazard ratio for each 10 year increase in paternal age was 1.47 (95% confidence interval 1.23 to 1.76) for schizophrenia and 1.12 (0.98 to 1.29) for non-schizophrenic non-affective psychosis. This association between paternal age and schizophrenia was present in those with no family history of the disorder (hazard ratio for each 10 year increase in paternal age 1.60, 1.32 to 1.92), but not in those with a family history (0.91, 0.44 to 1.89) (P = 0.04 for interaction). CONCLUSIONS: Advancing paternal age is an important independent risk factor for schizophrenia. The stronger association between paternal age and schizophrenia in people without a family history provides further evidence that accumulation of de novo mutations in paternal sperm contributes to the overall risk of schizophrenia.

SUBMITTER: Sipos A

PROVIDER: S-EPMC526116 | biostudies-other | 2004 Nov

REPOSITORIES: biostudies-other

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Paternal age and schizophrenia: a population based cohort study.

Sipos Attila A Rasmussen Finn F Harrison Glynn G Tynelius Per P Lewis Glyn G Leon David A DA Gunnell David D

BMJ (Clinical research ed.) 20041022 7474

<h4>Objective</h4>To investigate the association of paternal age at conception with the risk of offspring developing schizophrenia.<h4>Design</h4>A population based cohort study.<h4>Setting</h4>Sweden.<h4>Subjects</h4>754,330 people born in Sweden between 1973 and 1980 and still alive and resident in Sweden at age 16 years.<h4>Main outcome measures</h4>Hospital admission with schizophrenia or non-schizophrenic, non-affective psychosis.<h4>Results</h4>After adjustment for birth related exposures, ...[more]

PMID: 15501901

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Project description:BackgroundWhether infection with the hepatitis C virus (HCV) causes schizophrenia - and whether the associated risk reverses after anti-HCV therapy - is unknown; we aimed to investigate these topics.MethodsWe conducted a nationwide, population-based cohort study using the Taiwan National Health Insurance Research Database (TNHIRD). A diagnosis of schizophrenia was based on criteria from the International Classification of Diseases, 9th revision (295.xx).ResultsFrom 2003 to 2012, from a total population of 19 298 735, we enrolled 3 propensity-score-matched cohorts (1:2:2): HCV-treated (8931 HCV-infected patients who had received interferon-based therapy for ≥ 6 months); HCV-untreated (17 862); and HCV-uninfected (17 862) from the TNHIRD. Of the total sample (44 655), 82.81% (36 980) were 40 years of age or older. Of the 3 cohorts, the HCV-untreated group had the highest 9-year cumulative incidence of schizophrenia (0.870%, 95% confidence interval [CI] 0.556%-1.311%; p < 0.001); the HCV-treated (0.251%, 95% CI 0.091%-0.599%) and HCV-uninfected (0.118%, 95% CI 0.062%-0.213%) cohorts showed similar cumulative incidence of schizophrenia (p = 0.33). Multivariate Cox analyses showed that HCV positivity (hazard ratio [HR] 3.469, 95% CI 2.168-5.551) was independently associated with the development of schizophrenia. The HCV-untreated cohort also had the highest cumulative incidence of overall mortality (20.799%, 95% CI 18.739%-22.936%; p < 0.001); the HCV-treated (12.518%, 95% CI 8.707%-17.052%) and HCV uninfected (6.707%, 95% CI 5.533%-8.026%) cohorts showed similar cumulative incidence of mortality (p = 0.12).LimitationsWe were unable to determine the precise mechanism of the increased risk of schizophrenia in patients with HCV infection.ConclusionIn a population-based cohort (most aged ≥ 40 years), HCV positivity was a potential risk factor for the development of schizophrenia; the HCV-associated risk of schizophrenia might be reversed by interferon-based antiviral therapy.

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Paternal age and schizophrenia: a population based cohort study.

Publications

Paternal age and schizophrenia: a population based cohort study.

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