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HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

ABSTRACT: A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.

SUBMITTER: Kennedy MA

PROVIDER: S-EPMC52618 | biostudies-other | 1991 Oct

REPOSITORIES: biostudies-other

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HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

Kennedy M A MA Gonzalez-Sarmiento R R Kees U R UR Lampert F F Dear N N Boehm T T Rabbitts T H TH

Proceedings of the National Academy of Sciences of the United States of America 19911001 20

A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11 ...[more]

PMID: 1681546

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