Ontology highlight
ABSTRACT:
SUBMITTER: Grandy DK
PROVIDER: S-EPMC52675 | biostudies-other | 1991 Oct
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19911001 20
Three genes closely related to the D1 dopamine receptor were identified in the human genome. One of the genes lacks introns and encodes a functional human dopamine receptor, D5, whose deduced amino acid sequence is 49% identical to that of the human D1 receptor. Compared with the human D1 dopamine receptor, the D5 receptor displayed a higher affinity for dopamine and was able to stimulate a biphasic rather than a monophasic intracellular accumulation of cAMP. Neither of the other two genes was a ...[more]