Ontology highlight
ABSTRACT:
SUBMITTER: Konieczny V
PROVIDER: S-EPMC5276804 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Konieczny Vera V Tovey Stephen C SC Mataragka Stefania S Prole David L DL Taylor Colin W CW
Cell reports 20170101 3
Inositol 1,4,5-trisphosphate (IP<sub>3</sub>) stimulates Ca<sup>2+</sup> release from the endoplasmic reticulum (ER), and the response is potentiated by 3',5'-cyclic AMP (cAMP). We investigated this interaction in HEK293 cells using carbachol and parathyroid hormone (PTH) to stimulate formation of IP<sub>3</sub> and cAMP, respectively. PTH alone had no effect on the cytosolic Ca<sup>2+</sup> concentration, but it potentiated the Ca<sup>2+</sup> signals evoked by carbachol. Surprisingly, however, ...[more]