Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC5276807 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Chen Chong C Arai Itaru I Satterfield Rachel R Young Samuel M SM Jonas Peter P
Cell reports 20170101 3
GABAergic synapses in brain circuits generate inhibitory output signals with submillisecond latency and temporal precision. Whether the molecular identity of the release sensor contributes to these signaling properties remains unclear. Here, we examined the Ca<sup>2+</sup> sensor of exocytosis at GABAergic basket cell (BC) to Purkinje cell (PC) synapses in cerebellum. Immunolabeling suggested that BC terminals selectively expressed synaptotagmin 2 (Syt2), whereas synaptotagmin 1 (Syt1) was enric ...[more]