Direct Cardiac Cellular Reprogramming for Cardiac Regeneration.
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ABSTRACT:
SUBMITTER: Patel V
PROVIDER: S-EPMC5278776 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Publications
Direct Cardiac Cellular Reprogramming for Cardiac Regeneration.
Patel Vivekkumar V Mathison Megumi M Singh Vivek P VP Yang Jianchang J Rosengart Todd K TK
Current treatment options in cardiovascular medicine 20160901 9
<h4>Opinion statement</h4>Direct cardiac cellular reprogramming of endogenous cardiac fibroblasts directly into induced cardiomyocytes is a highly feasible, promising therapeutic option for patients with advanced heart failure. The most successful cardiac reprogramming strategy will likely be a multimodal approach involving an optimal combination of cardio-differentiating factors, suppression of fibroblast gene expression, and induction of angiogenic factors. ...[more]
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