Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody.
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ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC5283805 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Publications
Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody.
Wang Chao C Sun Wujin W Wright Grace G Wang Andrew Z AZ Gu Zhen Z
Advanced materials (Deerfield Beach, Fla.) 20160825 40
Inflammation-triggered combination delivery of anti-PD-1 antibody and CpG oligodeoxynucleotides (CpG ODNs) has been demonstrated to prevent cancer relapse utilizing postsurgical inflammatory response. The controlled release of anti-PD1 and CpG ODN by CpG DNA-based "nano-cocoons" can induce considerable immune response, which in turn significantly prolongs the survival time of mice. ...[more]
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