Ontology highlight
ABSTRACT:
SUBMITTER: Grzegorzewska AP
PROVIDER: S-EPMC5288696 | biostudies-other | 2017 Feb
REPOSITORIES: biostudies-other
Scientific reports 20170202
Pulmonary arterial hypertension (PAH) is a fatal condition for which there is no cure. Dimethyl Fumarate (DMF) is an FDA approved anti-oxidative and anti-inflammatory agent with a favorable safety record. The goal of this study was to assess the effectiveness of DMF as a therapy for PAH using patient-derived cells and murine models. We show that DMF treatment is effective in reversing hemodynamic changes, reducing inflammation, oxidative damage, and fibrosis in the experimental models of PAH and ...[more]