Ontology highlight
ABSTRACT:
SUBMITTER: Palamiuc L
PROVIDER: S-EPMC5290170 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Nature communications 20170127
Serotonin, a central neuromodulator with ancient ties to feeding and metabolism, is a major driver of body fat loss. However, mechanisms by which central serotonin action leads to fat loss remain unknown. Here, we report that the FLP-7 neuropeptide and its cognate receptor, NPR-22, function as the ligand-receptor pair that defines the neuroendocrine axis of serotonergic body fat loss in Caenorhabditis elegans. FLP-7 is secreted as a neuroendocrine peptide in proportion to fluctuations in neural ...[more]