Ontology highlight
ABSTRACT:
SUBMITTER: Park EJ
PROVIDER: S-EPMC5290814 | biostudies-other | 2016 Feb
REPOSITORIES: biostudies-other
EMBO reports 20160111 2
NgBR is a transmembrane protein identified as a Nogo-B-interacting protein and recently has been shown to be a subunit required for cis-prenyltransferase (cisPTase) activity. To investigate the integrated role of NgBR in vascular development, we have characterized endothelial-specific NgBR knockout embryos. Here, we show that endothelial-specific NgBR knockout results in embryonic lethality due to vascular development defects in yolk sac and embryo proper. Loss of NgBR in endothelial cells reduc ...[more]