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Cryptic bioactivity capacitated by synthetic hybrid plant peptides.


ABSTRACT: Evolution often diversifies a peptide hormone family into multiple subfamilies, which exert distinct activities by exclusive interaction with specific receptors. Here we show that systematic swapping of pre-existing variation in a subfamily of plant CLE peptide hormones leads to a synthetic bifunctional peptide that exerts activities beyond the original subfamily by interacting with multiple receptors. This approach provides new insights into the complexity and specificity of peptide signalling.

SUBMITTER: Hirakawa Y 

PROVIDER: S-EPMC5303819 | biostudies-other | 2017 Feb

REPOSITORIES: biostudies-other

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Cryptic bioactivity capacitated by synthetic hybrid plant peptides.

Hirakawa Yuki Y   Shinohara Hidefumi H   Welke Kai K   Irle Stephan S   Matsubayashi Yoshikatsu Y   Torii Keiko U KU   Uchida Naoyuki N  

Nature communications 20170206


Evolution often diversifies a peptide hormone family into multiple subfamilies, which exert distinct activities by exclusive interaction with specific receptors. Here we show that systematic swapping of pre-existing variation in a subfamily of plant CLE peptide hormones leads to a synthetic bifunctional peptide that exerts activities beyond the original subfamily by interacting with multiple receptors. This approach provides new insights into the complexity and specificity of peptide signalling. ...[more]

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