Ontology highlight
ABSTRACT:
SUBMITTER: Hirakawa Y
PROVIDER: S-EPMC5303819 | biostudies-other | 2017 Feb
REPOSITORIES: biostudies-other
Hirakawa Yuki Y Shinohara Hidefumi H Welke Kai K Irle Stephan S Matsubayashi Yoshikatsu Y Torii Keiko U KU Uchida Naoyuki N
Nature communications 20170206
Evolution often diversifies a peptide hormone family into multiple subfamilies, which exert distinct activities by exclusive interaction with specific receptors. Here we show that systematic swapping of pre-existing variation in a subfamily of plant CLE peptide hormones leads to a synthetic bifunctional peptide that exerts activities beyond the original subfamily by interacting with multiple receptors. This approach provides new insights into the complexity and specificity of peptide signalling. ...[more]