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T?-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis.

ABSTRACT: Iron oxide nanoparticles have long been studied as a T? contrast agent in MRI due to their superparamagnetic behavior. T?-based positive contrast, being much more favorable for clinical application due to brighter and more accurate signaling is, however, still limited to gadolinium- or manganese-based imaging tools. Though being the only available commercial positive-contrast agents, they lack an efficient argument when it comes to biological toxicity and their circulatory half-life in blood. The need arises to design a biocompatible contrast agent with a scope for easy surface functionalization for long circulation in blood and/or targeted imaging. We hereby propose an extremely fast microwave synthesis for fluorescein-labeled extremely-small iron oxide nanoparticles (fdIONP), in a single step, as a viable tool for cell labeling and T?-MRI. We demonstrate the capabilities of such an approach through high-quality magnetic resonance angiographic images of mice.

SUBMITTER: Bhavesh R

PROVIDER: S-EPMC5304808 | biostudies-other | 2015 Nov

REPOSITORIES: biostudies-other

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T₁-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis.

Bhavesh Riju R Lechuga-Vieco Ana V AV Ruiz-Cabello Jesús J Herranz Fernando F

Nanomaterials (Basel, Switzerland) 20151104 4

Iron oxide nanoparticles have long been studied as a T₂ contrast agent in MRI due to their superparamagnetic behavior. T₁-based positive contrast, being much more favorable for clinical application due to brighter and more accurate signaling is, however, still limited to gadolinium- or manganese-based imaging tools. Though being the only available commercial positive-contrast agents, they lack an efficient argument when it comes to biological toxicity and their circulatory half-life in blood. Th ...[more]

PMID: 28347101

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