Ontology highlight
ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC5311873 | biostudies-other | 2017 Feb
REPOSITORIES: biostudies-other
Wang Zhiding Z Sun Dejun D Chen Guojiang G Li Ge G Dou Shuaijie S Wang Renxi R Xiao He H Hou Chunmei C Li Yan Y Feng Jiannan J Shen Beifen B Han Gencheng G
Scientific reports 20170216
T cell immunoglobulin mucin-3 (Tim-3) is an immune checkpoint inhibitor and its dysregulation has been related to T cell tolerance and many immune disorders, such as tumors and infection tolerance. However, the physiopathology roles of Tim-3 in innate immunity remain elusive. Here, we demonstrate that Tim-3 inhibits macrophage phagocytosis of L. monocytogenes by inhibiting the nuclear erythroid 2-related factor 2 (Nrf2) signaling pathway and increases bacterial burden. Tim-3 signaling promotes N ...[more]