Transient auditory nerve demyelination as a new mechanism for hidden hearing loss.
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ABSTRACT:
SUBMITTER: Wan G
PROVIDER: S-EPMC5321746 | biostudies-other | 2017 Feb
REPOSITORIES: biostudies-other
Publications
Transient auditory nerve demyelination as a new mechanism for hidden hearing loss.
Wan Guoqiang G Corfas Gabriel G
Nature communications 20170217
Hidden hearing loss (HHL) is a recently described auditory neuropathy believed to contribute to speech discrimination and intelligibility deficits in people with normal audiological tests. Animals and humans with HHL have normal auditory thresholds but defective cochlear neurotransmission, that is, reduced suprathreshold amplitude of the sound-evoked auditory nerve compound action potential. Currently, the only cellular mechanism known for HHL is loss of inner hair cell synapses (synaptopathy). ...[more]
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