Ontology highlight
ABSTRACT:
SUBMITTER: Kim Y
PROVIDER: S-EPMC5332874 | biostudies-other | 2017
REPOSITORIES: biostudies-other
International journal of biological sciences 20170217 2
One of the DNA repair machineries is activated by Poly (ADP-ribose) Polymerase (PARP) enzyme. Particularly, this enzyme is involved in repair of damages to single-strand DNA, thus decreasing the chances of generating double-strand breaks in the genome. Therefore, the concept to block PARP enzymes by PARP inhibitor (PARPi) was appreciated in cancer treatment. PARPi has been designed and tested for many years and became a potential supplement for the conventional chemotherapy. However, increasing ...[more]