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Cancer cell behaviors mediated by dysregulated pH dynamics at a glance.

ABSTRACT: Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer cell behaviors, including proliferation, metastasis, metabolic adaptation and tumorigenesis. Emerging data suggest that the dysregulated pH of cancers enables these specific cell behaviors by altering the structure and function of selective pH-sensitive proteins, termed pH sensors. Recent findings also show that, by blocking pHi increases, cancer cell behaviors can be attenuated. This suggests ion transporter inhibition as an effective therapeutic approach, either singly or in combination with targeted therapies. In this Cell Science at a Glance article and accompanying poster, we highlight the interconnected roles of dysregulated pH dynamics in cancer initiation, progression and adaptation.

SUBMITTER: White KA

PROVIDER: S-EPMC5339414 | biostudies-other | 2017 Feb

REPOSITORIES: biostudies-other

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Cancer cell behaviors mediated by dysregulated pH dynamics at a glance.

White Katharine A KA Grillo-Hill Bree K BK Barber Diane L DL

Journal of cell science 20170201 4

Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pH<sub>i</sub>) and a decreased extracellular pH (pH<sub>e</sub>) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer cell behaviors, including proliferation, metastasis, metabolic adaptation and tumorigenesis. Emerging data suggest that the dysregulated pH of cancers enables these specific cell behaviors by altering the structur ...[more]

PMID: 28202602

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