Ontology highlight
ABSTRACT:
SUBMITTER: Yamada M
PROVIDER: S-EPMC5355644 | biostudies-other | 2017 Mar
REPOSITORIES: biostudies-other
Yamada Mitsutoshi M Egli Dieter D
Stem cell reports 20170224 3
Changes in oocyte quality can have great impact on the developmental potential of early embryos. Here we test whether nuclear genome transfer from a developmentally incompetent to a developmentally competent oocyte can restore developmental potential. Using in vitro oocyte aging as a model system we performed nuclear transfer in mouse oocytes at metaphase II or at the first interphase, and observed that development to the blastocyst stage and to term was as efficient as in control embryos. The i ...[more]