Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC5356823 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Wang Qi Q Cheng Ningning N Li Xuefei X Pan Hui H Li Chunyu C Ren Shengxiang S Su Chunxia C Cai Weijing W Zhao Chao C Zhang Limin L Zhou Caicun C
Oncotarget 20170101 2
The acquired drug resistance would influence the efficacy of cisplatin-based chemotherapy in non-small-cell lung cancer. The present study aimed to investigate the correlation of long non-coding RNA (lncRNA) H19 with cisplatin-resistance and clinical outcome in lung adenocarcinoma. In our study, the expression of H19 in cisplatin-resistant A549/DDP cells was unregulated. Knockdown of H19 restored the response of A549/DDP cells to cisplatin. H19-mediated chemosensitivity enhancement was associate ...[more]