Ontology highlight
ABSTRACT:
SUBMITTER: Lim SH
PROVIDER: S-EPMC5356878 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Oncotarget 20170101 2
We investigated the patients with solid cancers harboring Fms-like tyrosine kinase 3 (FLT3) amplification using targeted sequencing of tumor tissue specimen and FISH assay. Simultaneously, FLT3-amplified patient-derived cells (PDCs) were generated to evaluate the sensitivity to FLT3 inhibition. A patient with metastatic colon cancer who was previously treated with more than 3rd line cytotoxic chemotherapy was found to have FLT3 amplification and then received regorafenib showing partial response ...[more]