Magnitude-dependent response of osteoblasts regulated by compressive stress.
Ontology highlight
ABSTRACT:
SUBMITTER: Shen XQ
PROVIDER: S-EPMC5357902 | biostudies-other | 2017 Mar
REPOSITORIES: biostudies-other
Publications
Magnitude-dependent response of osteoblasts regulated by compressive stress.
Shen Xiao-Qing XQ Geng Yuan-Ming YM Liu Ping P Huang Xiang-Yu XY Li Shu-Yi SY Liu Chun-Dong CD Zhou Zheng Z Xu Ping-Ping PP
Scientific reports 20170320
The present study aimed to investigate the role of magnitude in adaptive response of osteoblasts exposed to compressive stress. Murine primary osteoblasts and MC3T3-E1 cells were exposed to compressive stress (0, 1, 2, 3, 4, and 5 g/cm<sup>2</sup>) in 3D culture. Cell viability was evaluated, and expression levels of Runx2, Alp, Ocn, Rankl, and Opg were examined. ALP activity in osteoblasts and TRAP activity in RAW264.7 cells co-cultured with MC3T3-E1 cells were assayed. Results showed that comp ...[more]
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