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Circulating tumor cell status monitors the treatment responses in breast cancer patients: a meta-analysis.

ABSTRACT: Whether circulating tumor cells (CTCs) can be used as an indicator of treatment response in breast cancer (BC) needs to be clarified. We addressed this issue by a meta-analysis. PubMed, EMBase and Cochrane library databases were searched in June 2016. Effect measures were estimated as pooled risk ratio (RR), odds ratio (OR) or mean difference by fixed- or random-effect models, according to heterogeneity of included studies. In total, 50 studies with 6712 patients were recruited. Overall analysis showed that there was a significant reduction of CTC-positive rate (RR?=?0.68, 95% CI: 0.61-0.76, P?

SUBMITTER: Yan WT 

PROVIDER: S-EPMC5364512 | biostudies-other | 2017 Mar

REPOSITORIES: biostudies-other

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Circulating tumor cell status monitors the treatment responses in breast cancer patients: a meta-analysis.

Yan Wen-Ting WT   Cui Xiang X   Chen Qing Q   Li Ya-Fei YF   Cui You-Hong YH   Wang Yan Y   Jiang Jun J  

Scientific reports 20170324

Whether circulating tumor cells (CTCs) can be used as an indicator of treatment response in breast cancer (BC) needs to be clarified. We addressed this issue by a meta-analysis. PubMed, EMBase and Cochrane library databases were searched in June 2016. Effect measures were estimated as pooled risk ratio (RR), odds ratio (OR) or mean difference by fixed- or random-effect models, according to heterogeneity of included studies. In total, 50 studies with 6712 patients were recruited. Overall analysis  ...[more]