Ontology highlight
ABSTRACT:
SUBMITTER: Leus NG
PROVIDER: S-EPMC5366870 | biostudies-other | 2017 Mar
REPOSITORIES: biostudies-other
Leus Niek G J NG van den Bosch Thea T van der Wouden Petra E PE Krist Kim K Ourailidou Maria E ME Eleftheriadis Nikolaos N Kistemaker Loes E M LE Bos Sophie S Gjaltema Rutger A F RA Mekonnen Solomon A SA Bischoff Rainer R Gosens Reinoud R Haisma Hidde J HJ Dekker Frank J FJ
Scientific reports 20170327
Chronic obstructive pulmonary disease (COPD) constitutes a major health burden. Studying underlying molecular mechanisms could lead to new therapeutic targets. Macrophages are orchestrators of COPD, by releasing pro-inflammatory cytokines. This process relies on transcription factors such as NF-κB, among others. NF-κB is regulated by lysine acetylation; a post-translational modification installed by histone acetyltransferases and removed by histone deacetylases (HDACs). We hypothesized that smal ...[more]