Conservation of the regulatory subunit for the Clp ATP-dependent protease in prokaryotes and eukaryotes.
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ABSTRACT:
SUBMITTER: Gottesman S
PROVIDER: S-EPMC53931 | biostudies-other | 1990 May
REPOSITORIES: biostudies-other
Publications
Conservation of the regulatory subunit for the Clp ATP-dependent protease in prokaryotes and eukaryotes.
Gottesman S S Squires C C Pichersky E E Carrington M M Hobbs M M Mattick J S JS Dalrymple B B Kuramitsu H H Shiroza T T Foster T T
Proceedings of the National Academy of Sciences of the United States of America 19900501 9
Bacteria, tomatoes, and trypanosomes all contain genes for a large protein with extensive homology to the regulatory subunit, ClpA, of the ATP-dependent protease of Escherichia coli, Clp. All members of the family have between 756 and 926 amino acids and contain two large regions, of 233 and 192 amino acids, each containing consensus sequences for nucleotide binding. Within these regions there is at least 85% similarity between the most distant members of the family. The high degree of similarit ...[more]
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