Ontology highlight
ABSTRACT:
SUBMITTER: Huang N
PROVIDER: S-EPMC5399293 | biostudies-other | 2017 Apr
REPOSITORIES: biostudies-other
Nature communications 20170419
In animal cells, the centrosome is the main microtubule-organizing centre where microtubules are nucleated and anchored. The centriole subdistal appendages (SDAs) are the key structures that anchor microtubules in interphase cells, but the composition and assembly mechanisms of SDAs are not well understood. Here, we reveal that centrosome-binding proteins, coiled-coil domain containing (CCDC) 120 and CCDC68 are two novel SDA components required for hierarchical SDA assembly in human cells. CCDC1 ...[more]