Ontology highlight
ABSTRACT:
SUBMITTER: Trevisiol A
PROVIDER: S-EPMC5415357 | biostudies-other | 2017 Apr
REPOSITORIES: biostudies-other
eLife 20170417
In several neurodegenerative diseases and myelin disorders, the degeneration profiles of myelinated axons are compatible with underlying energy deficits. However, it is presently impossible to measure selectively axonal ATP levels in the electrically active nervous system. We combined transgenic expression of an ATP-sensor in neurons of mice with confocal FRET imaging and electrophysiological recordings of acutely isolated optic nerves. This allowed us to monitor dynamic changes and activity-dep ...[more]